Systematic literature review on sterile injectable dates of use, stability and implications for use

Authors

DOI:

https://doi.org/10.70347/svsthya.v2i1.66

Keywords:

Drug Stability, patient safety, sterile injectable, dates of use, quality control, drug storage

Abstract

Beyond-use date (BUD) is crucial for the stability of injectable preparations. However, there is a knowledge gap and a lack of information regarding BUD determination in injection preparations. Therefore, a systematic review is needed to address the BUD of injection preparations. This study aimed to provide comprehensive insights into the stability, BUD data, and associated implications for injectable preparations through a systematic literature review approach. This study employed a systematic literature review guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The inclusion criteria were research articles from national and international journals discussing the BUD of sterile injection preparations published in the last 10 years. Fourteen of the 19 articles related to BUD were selected for analysis. The analysis revealed that the stability of the 19 sterile injection preparations was significantly influenced by the characteristics of the preparation, storage conditions, and type of drug. These factors substantially affect the effectiveness and safety of drugs. Intravenous sterile injections involve several critical steps to ensure the safety and efficacy of the medications used. Adhering to BUD guidelines for intravenous injections is crucial for maintaining drug quality, which can help prevent infections or adverse reactions in patients. The stability of sterile injection preparations, which is influenced by various factors, has direct implications for BUD determination. This review highlights the importance of considering these factors when determining BUD to ensure patient safety.

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Author Biographies

I Gst A A Gangga Samala Dewi, Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Lucienne Agatha Larasati Nugraha Putri, Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Lydia Devy Silalahi, Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

I Gusti Ayu Widha Paramistya Dewi, Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Meivanti Diva Hapsari, Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Julio Angga Purnama Dewa, Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Kadek Ayu Mas Sarayawati, Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

I Wayan Sindhu Wahyu Prasetya, Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Ni Pande Kadek Sinta Dewi, Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Ni Putu Rika Noviyanti, Departement of Pharmacist, FacuPharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayanalty Mathematics and Natural Sciences, Udayana University

Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Putri Ayu Puspita Sari , Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Ni Kadek Ida Rajeswari, Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Ni Luh Komang Wahyuni, Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Dewi Wulandari, Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

Ni Kadek Warditiani, Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences Udayana University, Jln. P.B. Sudirman, Denpasar, Bali

Pharmacist Professional Program, Faculty of Mathematics and Natural Sciences, Universitas Udayana

 

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Published

2025-01-12

How to Cite

Dewi, I. G. A. A. G. S., Putri, L. A. L. N., Silalahi, L. D., Dewi, I. G. A. W. P., Hapsari, M. D., Dewa, J. A. P., … Warditiani, N. K. (2025). Systematic literature review on sterile injectable dates of use, stability and implications for use. Svāsthya: Trends in General Medicine and Public Health, 2(1), e66. https://doi.org/10.70347/svsthya.v2i1.66

Issue

Section

Systematic review - Meta analysis